Mike Wilhelmer Zuurman
 Personal Information
 Contact information
Department and Institution
Internal Medicine/Nephrology/Medical Biomics
University Medical Centre Groningen
Prof. Dr. ROB Gans
A. Deusinglaan 1
Building 3215, 4.22
Email address: mailto:firstname.lastname@example.org
Prof. Dr. G.J.Navis
 Research fields
Epidemiology, Heredity/Genetics/Development, Hypertension, Inflammatory processes and renal pathology, Mediators, signalling, cell growth, apoptosis, neoplasia
 Current research
The research is part of the GUIDE Breedtestrategie project that aimes at finding the genetic determinants of complex traits such as atherosclerosis and other processes that ultimately lead to renal and vascular end-organ damage.
Inflammation plays a pivotal role in the atherosclerotic process with chemokines and chemokine receptors important players in the events leading to and during plaque formation. This type of chronic vascular inflammation underlies diseases that lead to end-organ damage.
Genetic variation and environmental influences interact to give rise to complex traits. It has been proposed that single genetic changes play a small role in pathology, but that many different variants together - along with many environmental factors - contribute to disease. Indeed, genetic variants may show no association with disease in univariate analyses, it especially in combination with other risk factors that the effect of genetic variation may surface.
In our research we focus on uncovering the underlying genetic variants that modify susceptibility to important renal and cardiovascular dieseases. In particular, single nucleotide polymorphisms, microsatellites, haplotypes and other genetic differences in genes of the immune system between subjects in different study cohorts (e.g. the general population-based PREVEND, NECOSAD)and their putative associations with various outcome parameters are investigated.
Functional studies of the genetic variants in terms of cel physiology, pharmacology and messenger cascades are the next step in our extensive research.
Complex trait, Inflammation, Atherosclerosis, Renal-Cardiac Axis, chemokines, pharmacology, renal function, biostatistics, genetic variation
 Patient populations
|No.||Cell line||Cell type||Species||Origin|
|2||HEK293||Human embryo kidney||Human||Immortalized|
 In vitro assays
Migration (chemotaxis), ELISA, others
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